SandboxAQ has announced a collaboration with NVIDIA to accelerate breakthroughs in biopharmaceuticals, chemicals, advanced materials, financial services, cybersecurity, navigation, and medical imaging. A member of the NVIDIA Inception program, SandboxAQ isleveraging NVIDIA DGX Cloud on Google Cloud to build a state-of-the-art large quantitative model (LQM) platform, fueling AI-driven scientific discovery.
SandboxAQ’s proprietary LQMs are designed to solve complex, high-stakes problems with speed, precision, and scalability. Built for domains where traditional models fall short, the platform delivers deterministic, physics-based results across critical enterprise sectors.
Using DGX Cloud, SandboxAQ replaces conventional design-make-test cycles with high-performance, equation-based simulations—reducing discovery timelines from months to weeks. Simultaneous optimization across multiple parameters enables faster validation of promising candidates and more confident decision-making. The company is also generating high-fidelity scientific datasets through combined chemical and biological simulations. These equation-based LQMs reveal previously undetectable interactions between small molecules and complex biological targets, improving predictive model accuracy and reducing false positives. SandboxAQ’s AI Chemist further advances the platform by orchestrating multiple LQMs to autonomously explore millions of chemical pathways, enabling the discovery of novel molecules at a scale far beyond human capability.
The announcement builds on prior joint research milestones. In 2024, SandboxAQ and NVIDIA achieved an 80x acceleration in quantum chemistry calculations using CUDA-accelerated Density Matrix Renormalization Group (DMRG), enabling simulation of enzyme active sites and complex catalysts that were previously computationally prohibitive. In 2025, the companies published Orbital Optimization of Large Active Spaces via AI-Accelerators, demonstrating orbital optimization of a system with 82 electrons in 82 orbitals—more than doubling the size of previous simulations. This advance significantly expands the frontier of GPU-accelerated quantum chemistry, with implications across catalysis, materials science, and high-dimensional parameter optimization.
SandboxAQ’s enhanced platform is delivering measurable outcomes across critical industries. In biopharma and healthcare, it accelerates preclinical development by improving prediction of drug efficacy and safety. In the chemicals and materials sectors, it enables faster discovery and validation of sustainable chemical processes, such as carbon and hydrogen utilization and energy storage. In cybersecurity and infrastructure, advanced modeling capabilities support improved agility, resilience, and proactive threat management.
SandboxAQ’s LQMs represent a new category of enterprise AI. Unlike generalized frontier models, they are grounded in the fundamental laws of physics, chemistry, biology, and economics, delivering scientifically reliable outcomes. In life sciences, LQMs are trained on high-fidelity, domain-specific datasets to improve model accuracy, reduce false positives, and accelerate the path from hypothesis to therapeutic insight. This scientific rigor sets the platform apart in a growing field of AI-based solutions.
“Our expanded work with NVIDIA accelerates our customers’ ability to innovate and lead in their fields,” said Jack Hidary, CEO of SandboxAQ. “By developing our platform on NVIDIA DGX Cloud and continuing our research collaboration, SandboxAQ will deliver a level of performance and insight that gives our customers a clear edge in accelerating innovation.”
“SandboxAQ is pushing the boundaries of AI-native science,” said Alexis Bjorlin, Vice President of NVIDIA DGX Cloud. “NVIDIA DGX Cloud provides an AI development platform with essential scale and optimized application performance, empowering SandboxAQ to deliver cutting-edge capabilities and drive real-world impact for organizations tackling society’s most critical challenges.”
About SandboxAQ
SandboxAQ is a B2B company delivering solutions at the intersection of AI and quantum techniques. Its Large Quantitative Models (LQMs) enable critical advances in life sciences, financial services, navigation, and other sectors. The company spun out of Alphabet Inc. as an independent, growth-backed firm supported by strategic partners and investors, including T. Rowe Price Associates, Alger Management, IQT, the US Innovative Technology Fund, S32, Paladin Capital, BNP Paribas, Hillspire, Breyer Capital, Ray Dalio, Marc Benioff, Thomas Tull, Yann LeCun, and others. For more information, visit www.sandboxaq.com.
About NVIDIA
Founded in 1993, NVIDIA is a global leader in accelerated computing and artificial intelligence. The company’s innovations span graphics, data centers, AI, and scientific computing. NVIDIA DGX Cloud is a platform for developing and deploying large-scale AI models, combining optimized infrastructure with a scalable cloud-based environment. For more information, visit www.nvidia.com.
(Editor’s Note: All trademarks mentioned in this article, including company names, product names, and logos, are the property of their respective owners. Use of these trademarks is for informational purposes only and does not imply any endorsement.)
